Granulation tissue is the perfused, fibrous connective tissue that replaces a fibrin clot in healing wounds. Granulation tissue typically grows from the base of a wound and is able to fill wounds of almost any size it heals.
During the proliferative phase of wound healing, granulation tissue is:
- light red or dark pink in color, being perfused (permeated) with new capillary loops or "buds";
- soft to the touch;
- moist; and
- bumpy (granular) in appearance.
Granulation tissue is composed of tissue matrix supporting a variety of cell types, most of which can be associated with one of the following functions:
- extracellular matrix,
- immune system, or
An excess of granulation tissue (caro luxurians) is informally referred to as "proud flesh."
In vaginoplasty, performed as part of gender reassignment surgery for trans women, granulation can occur during the healing process within the vagina causing a degree of pain and discomfort during dilation. Usually this can be repaired by cauterising with Silver Nitrate.
- Healing and Repair Chapter 9 from an "Introduction to Pathology" on a Tuskegee University website
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