Granulation tissue

From Susan's Place Transgender Resources
Jump to: navigation, search

Granulation tissue is the perfused, fibrous connective tissue that replaces a fibrin clot in healing wounds. Granulation tissue typically grows from the base of a wound and is able to fill wounds of almost any size it heals.


During the proliferative phase of wound healing, granulation tissue is:

  • light red or dark pink in color, being perfused (permeated) with new capillary loops or "buds";
  • soft to the touch;
  • moist; and
  • bumpy (granular) in appearance.


Granulation tissue is composed of tissue matrix supporting a variety of cell types, most of which can be associated with one of the following functions:

  • extracellular matrix,
  • immune system, or
  • vascularisation.

An excess of granulation tissue (caro luxurians) is informally referred to as "proud flesh."[1]


In vaginoplasty, performed as part of gender reassignment surgery for trans women, granulation can occur during the healing process within the vagina causing a degree of pain and discomfort during dilation. Usually this can be repaired by cauterising with Silver Nitrate.


  1. Healing and Repair Chapter 9 from an "Introduction to Pathology" on a Tuskegee University website


*Some information provided in whole or in part by