5-alpha reductase is an enzyme (EC 188.8.131.52) that converts testosterone, the male sex hormone, into dihydrotestosterone. There are two isoenzymes, steroid 5-alpha reductase 1 and 2 (SRD5A1 and SRD5A2). The second isoenzyme is deficient in 5-alpha-reductase deficiency, which leads to a form of intersexualism.
SRD5A1 is located on chromosome 5p15, while SRD5A2 is located on 2p23.
Finasteride inhibits the function of only one of the isoenzymes (type 1), while dutasteride inhibits both forms. These drugs are used in benign prostatic hyperplasia, prostate cancer and baldness (finasteride).
- Readers may use this email link to report errors and/or omissions they have discovered, or to add additional material or comments regarding this article "5-alpha reductase"
- Wiki Staff should discuss this article in the Wiki Staff Forum
- Susan's Place Transgender Resources Forums
- Susan's Place Transgender Chat
Browse: Gender | Cross-dressing | Intersexuality | Transgender topics | Transsexualism | Hormone Therapy | Surgery | Standards of Care | Legal Information | Psychology | Transitioning | Family & Friends | People | Books | Abbreviations | Browse All TopicsRead the FAQ | Return to the Main Page
Want to help us? Write New Articles and/or Expand Current Articles
*Some information provided in whole or in part by http://en.wikipedia.org/